SOLIDARITY Plus trial for promising drugs will roll out in 52 countries and the World Health Organisation says it is an unprecedented global collaboration for the COVID-19 pandemic.
Aug. 15, 2021
2 min read
SOLIDARITY Plus trial to be launched against Covid-19
WHO director general Dr Tedros Adhanom Ghebreyesus
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WHO has announced the next phase in its Solidarity trial saying it will enroll hospitalised patients to test three new drugs on hospitalised COVID-19 patients.
WHO Chief, Dr Tedros Ghebreyesus says these therapies artesunate, imatinib and infliximab were selected by an independent expert panel for their potential in reducing the risk of death on hospitalised COVID-19 patients.
He said they are already used for other indications, adding that artesunate is used for severe malaria, imatinib for certain cancers, and infliximab for diseases of the immune system such as Crohn’s Disease and rheumatoid arthritis.
These drugs, he said were donated for the trial by their manufacturers.
“Finding more effective and accessible therapeutics for COVID-19 patients remains a critical need, and WHO is proud to lead this global effort, and I would like to thank the participating governments, pharmaceutical companies, hospitals, clinicians and patients, who have come together to do this in true global solidarity,'' said Dr Ghebreyesus.
Solidarity PLUS trial is a platform trial that represents the largest global collaboration among WHO Member States. It involves thousands of researchers in over 600 hospitals in 52 countries, 16 more countries than the first phase of trials.
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This is reported by WHO to allow the trial to assess multiple treatments at the same time using a single protocol, recruiting thousands of patients to generate robust estimates on the effect a drug may have on mortality, even moderate effects.
It also allows new treatments to be added and ineffective treatments to be dropped throughout the course of the trial.
Previously, four drugs were evaluated by the trial. The results showed that remdesivir, hydroxychloroquine, lopinavir and interferon had little or no effect on hospitalised patients with COVID-19.
Through the Solidarity PLUS trial, researchers across the world have an opportunity to use their expertise and resources to contribute to global COVID-19 research. LeNA